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In this study, we defined a localized DLBCL as DLBCL with Ann Arbor stage I or non-bulky ( http://www.selleckchem.com/products/BI-2536.html OS nor PFS differ between these treatment groups. The 3-year OS were 85.5% in Chemo group and 96.2% in CMT group, respectively (P=0.23). The 3-year PFS were 74.3% in Chemo group and 89.7% in CMT group, respectively (P=0.19). A multivariate Cox regression model showed that CMT group have a tendency to improve OS [hazard ratio =0.33; 95% confidence interval 0.10�C1.06; P =0.06] compared with Chemo group. Grade 3 to 4 neutropenia and neutopenic fever were more frequent in patients with Chemo group (P http://www.selleckchem.com/products/Cyclopamine.html be superior to chemo group in terms of safety. IMAGING http://www.selleck.cn/products/gsk126.html 486 EVALUATION OF THE PROGNOSTIC VALUE OF INITIAL METABOLIC TUMOR VOLUME MEASURED BY TEP-FDG IN HODGKIN'S LYMPHOMA M. Touati,1 M. Boulesteix,2 J. Abraham,3 S. Verbeke,2 A. El Badaoui,2 M. Gourin,3 A. Olivrie,1 M. Delage Corre,4 B. Marin,5 A. Jaccard,1 J. Monteil,2 D. Bordessoule.1 1Hematologie Clinique et Therapie Cellulaire, Centre Hospitalier Universitaire, Limoges, France, 2Medecine Nucleaire, Centre Hospitalier Universitaire, Limoges, France, 3Hematologie Clinique et Therapie Cellulaire, Centre Hospitalier Universitaire, Limoges, France, 4Laboratoire de Pathologie, Centre Hospitalier Universitaire, Limoges, France, 5Unite Fonctionnelle Biostatistique et Informatique Medicale, Centre Hospitalier Universitaire, Limoges, France Introduction: Approximately 15% of patients (pts) with classical Hodgkin lymphoma (cHL) are unpredictably refractory or relapsed, justifying the identification of new prognostic tools. Morphological initial tumor volume is a recognized prognostic factor, so metabolic tumor volume (MTV) measured by FDG-PET should be explored. The main objective of this study was to determine the prognostic value of MTV and potential correlation with macrophages CD68 expression. Patients and method: The study focused on 46 histologically proven cHL pts with available CD68 immunostaining and quantitative initial and post-C2 SUV (Standardized Uptake Value) FDG-PET data.