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01 pb http://www.selleckchem.com/products/LDE225(NVP-LDE225).html on metformin monotherapy, patients who took antidiabetic drugs other than metformin, and patients who took metformin combined with other antidiabetic drugs. Compared with patients who did not have type 2 diabetes, two groups had adjusted HRs greater than 1.0: the group who took no antidiabetic drugs and the group who received metformin monotherapy. The adjusted HRs were 1.58 (95% confidence interval [CI] 1.47�C1.68) and 1.50 (95% CI 1.32�C1.71), respectively. Patients who took antidiabetic drugs other than metformin http://en.wikipedia.org/wiki/Levetiracetam had an adjusted HR of 0.95 (95% CI 0.81�C1.12). These results suggest that type 2 diabetes increased the risk of cancer in the study patients. A significant decrease in cancer risk was noted in the combination group (i.e., metformin with other antidiabetic drugs), the adjusted HRs of which were 0.94 (95% CI 0.90�C0.98, p