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In response to this trust, we hope to share with all of our researchers our sense of pride and accomplishment gained from contributing to the academic community. We welcome submissions from a wide range of contributors. The authors declare no conflict of interest. ""Aim:? http://www.selleckchem.com/products/MDV3100.html To evaluate long-term, multiple risk factor intervention on physical, psychological and mental prognosis, and development of complications and cardiovascular disease in elderly type?2 diabetes patients. Methods:? Our randomized, controlled, multicenter, prospective intervention trial included 1173 elderly type?2 diabetes patients who were enrolled from 39 Japanese institutions and randomized to an intensive or conservative treatment group. Glycemic control, dyslipidemia, hypertension, http://www.selleckchem.com/products/gsk1120212-jtp-74057.html obesity, diabetic complications and atherosclerotic disease were measured annually. Instrumental activity of daily living, cognitive impairment, depressive symptoms and diabetes burden were assessed at baseline and 3?years. Results:? There was no significant difference in clinical or cognitive parameters at baseline between the two groups. The prevalence of low activities of daily living, depressive symptoms and cognitive impairment was 13%, 28% and 4%, respectively, and was similar in the two groups. A small, but significant difference in HbA1c between the two groups was observed at 1 year after the start of intervention (7.9% vs 8.1%, P? http://www.selleck.cn/products/pd-1-pd-l1-inhibitor-2.html This study showed no significant differences in fatal or non-fatal events between intensive and conventional treatment. The present study might clarify whether treatment of risk factors influences function and quality of life in elderly diabetic patients. Geriatr Gerontol Int 2012; 12 (Suppl. 1): 7�C17. The prevalence of diabetes increases with age, with approximately 15% of elderly people in Japan having the disorder.1 These patients often suffer from diabetic microvascular and macrovascular complications.2 Treatment goals in this elderly diabetic population are to maintain functional abilities and quality of life, and to prevent diabetic complications. Physical functional activities3,4 and cognitive function5,6 are more impaired in elderly diabetic patients, with depression and low well-being being major concerns.7,8 It is therefore important to evaluate the effects of clinical interventions on physical, psychological and mental functions, as well as on disease-related variables, such as diabetic complications, atherosclerotic disease and mortality.