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580, 50.567)?=?5.366, p?=?0.012] and treatment for FSFI total score [F(1, 32)?=?4.243, p?=?0.048]. At the end of the fourth week, patients in the saffron group had experienced significantly more improvement in total FSFI (p? http://www.selleck.cn/products/ve-822.html Montejo-Gonzalez et al., 1997; Hensley & Nurnberg, 2002; Serretti & Chiesa, 2009, Montejo et al., 2011). Increasing the use of these agents in affective and anxiety disorders has resulted in increasing the number of patients suffering from SSRI-induced sexual dysfunction (Hensley & Nurnberg, 2002). Women are at higher risk for mood and anxiety disorders as well as many other psychiatric disorders in which SSRIs are commonly being used (Hensley & Nurnberg, 2002). Thus, women are more exposed to SSRIs and might therefore be more likely to experience the sexual side effects of these drugs. It has been reported that severity of sexual dysfunction is generally higher in women (Hensley & Nurnberg, 2002). All SSRIs including commonly http://www.selleckchem.com/products/Trichostatin-A.html used fluoxetine can cause sexual dysfunction (Sidi et al., 2012). Several strategies have been used to treat or decrease the sexual side effects of SSRIs. Several agents such as sildenafil (Gupta et al., 1999), buspirone (Landen et al., 1999), cyproheptadine http://www.selleckchem.com/products/pd-0332991-palbociclib-isethionate.html (Aizenberg et al., 1995), bupropion (Clayton et al., 2001), and amantadine (Woodrum & Brown, 1998) have been used for treatment of SSRI-induced sexual dysfunction with variable success rates. Many of these agents are associated with significant side effects, and some are even associated with reversal of antidepressant or anti-anxiety effects of SSRIs (Feder, 1991). Saffron (Crocus sativus L.) and its extract are used as a medicinal plant in traditional medicine. Several controlled and uncontrolled studies have shown its beneficial antidepressant and anti-dementia effects (Akhondzadeh et al., 2004; Akhondzadeh et al., 2005; Akhondzadeh Basti et al., 2007; Agha-Hosseini et al., 2008; Akhondzadeh, et al., 2010a,2010b). There are also many less studied claims about the other effects of saffron. Two important components of saffron are crocin and safranal. Some animal and human studies have shown the beneficial effects of saffron and particularly its crocin component on sexual function (Hosseinzadeh et al.