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EKGs were done at eight different time points. QT-intervals, QT-dispersion, and TpTe were measured at each time point. Harmonic regression was used to model circadian periodicity, P http://www.selleck.cn/products/PLX-4720.html http://www.selleckchem.com/products/avelestat-azd9668.html also had a significant circadian variation that was not affected by gender in the majority of leads. Conclusions: A circadian variation exists in the dispersion of myocardial repolarization, as measured by both TpTe and QT-dispersion. Men and women have a different circadian variation pattern. Further studies regarding the mechanisms and clinical implications are needed. Ann Noninvasive Electrocardiol 2010;15(1):3�C10 ""Systemic lupus erythematosus (SLE) is a chronic disease that affects many organ systems and manifests a broad spectrum of laboratory and clinical features. SLE patients have an increased risk of developing cardiovascular disease. The aim of this study was to evaluate inhomogeneities of repolarization by using Tpeak�CTend (Tp�Ce) interval and Tp�Ce/QT ratio were measured from the 12-lead surface electrocardiogram (ECG) in patients with SLE. This study included 69 SLE patients (69 females; mean age 35.8 �� 10.2) and 57 control subjects (57 females; mean age 34.5 �� 8.9). Transthoracic echocardiographic examination was done in all participants. QT parameters, Tp�Ce intervals and Tp�Ce/QT ratio were measured from the 12-lead ECG. These parameters were compared between groups. No statistically significant difference was found between two groups in terms of basic characteristics. Diastolic function parameters were similar between the two groups (P > 0.05). In http://www.selleckchem.com/products/a-1331852.html electrocardiographic parameters analysis, QT dispersion (QTd) and corrected QT dispersion (cQTd) were significantly increased in SLE patients compared the control group (49.5 �� 16.4 ms vs. 32.8��11.7 ms and 56.7 �� 19.5 ms vs. 36.4 �� 13.1 ms, all P value