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The proposed combined LLR and parallel imaging method has better performance than the two methods alone, especially with highly accelerated acquisition. Magn Reson Med, 2014. ? 2014 Wiley Periodicals, Inc. ""Recently, http://www.selleckchem.com/products/PLX-4032.html a new and fast three-dimensional imaging technique for magnetization transfer ratio (MTR) imaging has been proposed based on a balanced steady-state free precession protocol with modified radiofrequency pulses. In this study, optimal balanced steady-state free precession MTR protocol parameters were derived for maximum stability and reproducibility. Variability between scans was assessed within white and gray matter for nine healthy volunteers using two different 1.5 T clinical systems at six different sites. Intrascanner and interscanner MTR measurements were well reproducible (coefficient of variation: cv http://www.selleck.cn/products/U0126.html for optimal flip angle settings. This study demonstrates that balanced steady-state free precession MTR not only benefits from short acquisition time and high signal-to-noise ratio but also offers excellent reproducibility and low variability, and it is thus proposed for clinical MTR scans at individual sites as well as for multicenter studies. Magn Reson Med, 2010. ? 2010 Wiley-Liss, Inc. ""In vivo radiofrequency (RF) field B1 mapping represents an essential prerequisite for parallel transmit applications. However, the large dynamic range of the transmit fields of the individual coil elements challenges the accuracy of MR-based B1 mapping techniques. In the present work, the B1 mapping error and its impact on the RF performance are studied based on a coil eigenmode analysis. Furthermore, the linear properties of the transmit chain are exploited to virtually adjust the weighting of the different coil eigenmodes in the B1 mapping procedure, resulting in considerably reduced mapping errors. In addition, the weighting of the eigenmodes is tailored to potential target applications, e.g., specific absorption rate (SAR) reduced http://www.selleckchem.com/products/INCB18424.html RF shimming or multidimensional RF pulses, resulting in improved RF performance. The basic theoretic principles of the concept are elaborated and validated by corresponding simulations. Furthermore, results on B1 mapping and RF shimming experiments, performed on phantoms and in vivo using a 3-T scanner equipped with an eight-channel transmit/receive body coil, are presented to prove the feasibility of the approach. Magn Reson Med, 2010. ? 2010 Wiley-Liss, Inc. ""There is increasing interest in the J-PRESS technique, an in vivo implementation of two-dimensional J-spectroscopy combined with PRESS localization, for high-field spectroscopy studies of the human brain.