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Additional cut-off values (up to 3 mm, up to 5 mm residual disease) were also investigated. Sample size was calculated on the basis of Simon design in order to detect a 15% difference in the accuracy between the 2 imaging modalities; considering the MRI diagnostic accuracy = 75% (p0), an �� type 1 error = 0.01, and a �� type II error = 0.1 (power = 90%), a total of 86 patients was required. Taking into account a drop out rate around 10%, a sample size of at least 95 patients was planned. Sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and accuracy were calculated using standard formulas. The pretest probability and posttest probability values for MRI and PET/CT were also calculated. http://www.selleckchem.com/products/epz-5676.html The 95% confidence intervals were determined for each parameter. Sensitivity, specificity, and accuracy were compared using the McNemar test. The diagnostic performances of MRI and PET/CT were calculated on a per-patient as well as on a per-lesion basis: the lesion-based analysis was conducted considering residual disease in http://www.selleck.cn/products/Staurosporine.html the cervix (n = 96), lymph node groups (n = 425), and in the whole series (n = 521). Lymph node groups included aortic and pelvic lymph nodes represented by lower and upper pelvic lymph nodes, bilaterally.27 A 2-sided P http://www.selleckchem.com/products/ly2109761.html surgery were incomplete recovery from neoadjuvant treatment (n = 13) and logistic problems (n = 5). At pathological examination, residual tumor in the cervix was absent in 31 (32.3%) patients; in the remaining patients, it ranged between 1 and 30 mm (median, 16 mm). Overall, metastatic involvement of pelvic lymph nodes was documented in 25 (26.0%) patients, and aortic lymph node involvement was documented in 11 (27.5%) patients. Fifty-six out of 425 lymph node groups (13.2%) were metastatic. In the whole series, sensitivity was higher for MRI than for PET/CT (P = .0001), whereas specificity was higher for PET/CT (P = .0001). No difference was found with accuracy (Table 2). We then analyzed MRI and PET/CT diagnostic performances separately for residual disease in the cervix (Table 3).