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In our study, results underwent cross-subject statistics with family-wise error http://www.selleckchem.com/products/Bortezomib.html correction for multiple comparisons using cluster-based thresholding (t?>?3; p? http://www.selleck.cn/products/bgj398-nvp-bgj398.html of inspired oxygen and maximum base excess during the first 12?h, and presence of congenital malformations), Apgar score, presence of sepsis, use of mechanical ventilation, presence of patent ductus arteriosus (PDA), use of ibuprofen for treatment of PDA, surgical ligation of PDA, bronchopulmonary dysplasia (BPD, supplemental oxygen at 36?weeks GA), prenatal and postnatal (betamethasone at a maximal cumulative dose of 1.7?mg/kg) use of steroids, necrotising enterocolitis and retinopathy of prematurity. Linear regression analyses within TBSS were then performed with the variables that were significantly correlated with FA or MD in the univariate analyses, to examine the contribution of those individual variables to explaining variation on FA and MD. All TBSS results were corrected for multiple comparisons, using cluster-based thresholding (t?>?3; p? http://www.selleckchem.com/products/gsk1120212-jtp-74057.html between diffusion measures and examined risk factors. GA at birth was entered into each model. Analyses were performed in SPSS 19.0 (IBM Corporation, Somers, NY, USA). Beta-coefficients and R2 values were calculated, and the standard error of the estimate was obtained for each model. Comparisons of clinical variables between groups were performed with Student's t-test for numerical measures and with chi-square or Fisher's exact test for categorical data. Significance level was specified at p?