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The ToC was higher in men (p http://www.selleckchem.com/products/cb-5083.html pre- and post-MP women showed a linear ToC 4 (y)/14 (x) relationship (r=.865, p http://www.selleck.cn/products/PD-0332991.html bone tends to be lost faster than cortical bone, the C4/C14 ToC ratio would evaluate the loss in mechanical efficiency of the trabecular structure with reference to the cortical mass of the same individual, avoiding comparison with younger subjects http://www.selleckchem.com/products/a-1155463.html as required by DXA. Thus, a Z-scored version of the C4/C14 graph obtained can be used as a standard reference for comparative diagnoses as well as for comparison with the muscular status of the individual. This simple study offers a non-invasive, biomechanical diagnosis of osteoporosis as an ��osteopenic fragility�� in agreement with the NIH criteria, based in relevant features of the same individual, and independent of age, gender, or anthropometric traits. Disclosures: Jose Ferretti, None. MO0032 Decay of Bone Microarchitecture in Men with Prostate Cancer During the First 12 Months of Androgen Deprivation Therapy.Emma Hamiton1, Emily Gianatti1, Ali Ghasem Zadeh1, Daryl Lim Joon2, Damien Bolton1, Roger Zebase1, Jeffrey Zajac*3, Ego Seeman4, Mathis Grossmann1. 1University of Melbourne, Australia, 2Austin Health, Australia, 3Austin & Repatriation Medical Centre, Australia, 4Austin Health, University of Melbourne, Australia Context: Androgen deprivation therapy (ADT) used in the treatment of prostate cancer reduces bone mineral density (BMD) and predisposes to fractures. The structural basis of the BMD deficit and bone fragility is uncertain. Objective and Patients: We investigated changes in bone microarchitecture in 26 men (70.6 �� 6.