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""While kidney transplant recipients of African http://www.selleckchem.com/products/Everolimus(RAD001).html American (AA) descent are frequently considered at increased risk of acute rejection, the value of induction therapy is not defined in settings of lower immunologic risk and modern immunosuppression. Using the Scientific Registry of Transplant Recipients database, we identified 23?244 primary kidney transplant recipients with panel-reactive antibody (PRA)?=?0% treated with TAC/MPA and prednisone from 2000 to 2008. We compared acute rejection, graft survival (GS), and patient survival rates among AA and non-AA and further stratified by induction therapy (none, IL2ra, or rATG). One-yr acute rejection was higher in AA than in non-AA overall (14.5% vs. 9.9%, hazard ratio [HR] for acute rejection [AR] 1.43, p? and IL2ra (adjusted RR 0.80, CI 0.68�C0.93) were similarly effective in reducing AR rates, but did not reach comparable outcomes as in non-AA. African Americans who are at otherwise lower immunologic risk have a higher risk of rejection despite modern immunosuppression. Depleting or non-depleting induction therapy similarly reduces but does not entirely mitigate this increased risk, with no impact on three-yr GS. ""Fridell JA, Mangus RS, Taber TE, Goble ML, Milgrom ML, Good J, Vetor R, Powelson JA. Growth of a nation part II: impact of recipient obesity on whole-organ pancreas transplantation. Clin Transplant 2011: 25: E366�CE374. ? 2011 John Wiley & Sons A/S. Abstract:? Obesity has reached epidemic proportions in the USA. Consequently, there is an increasing number of obese diabetic patients who would otherwise be appropriate candidates for pancreas transplantation (PTx). This is a retrospective study of all PTx performed at Indiana University between 2003 and 2009 (n?=?308) comparing recipients with body mass index (BMI)?