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Groups D and E were treated with ofatumumab via tail vein injection at 1 or 10?mg/kg on days +3, +7, +10 and +14. Animals were observed for up to a 90-d time-period. The end-point of the study was survival defined as time to development of limb paralysis. Animals that reached the end-point or survived after 3?months of observation were sacrificed. In vivo experiments were performed on four occasions. Results were pooled for final analysis with a total of 28 mice per treatment group. All experiments were performed in triplicates on three separate occasions. Data was plotted and analysed using SPSS 14.0 for Windows 2003 software (IBM, Armonk, NY, USA). For in vitro studies (ADCC and CMC assays), statistical differences between treatment groups and controls were determined by unpaired http://www.selleckchem.com/products/Nolvadex.html students t-test. In addition, survival curves were generated using theKaplan-Meier method. Differences in survival were compared by log rank testing. A P-value of http://www.selleckchem.com/products/Fludarabine(Fludara).html at the lower ofatumumab concentration (i.e. 1?��g/ml) in Raji, Ramos, and U-698-M (U2932 cells were not tested at the 1?��g/ml dose level). No differences between rituximab and ofatumumab anti-tumour activity were observed in RL and SU-DHL-5 cells. Ofatumumab was also active in rituximab-resistant cell lines (Fig?1). In Raji 4RH and RL 4RH cells, ofatumumab was more active than rituximab. No differences in mAb-associated ADCC were observed in all cell lines (not shown). In order to compare the activity of ofatumumab and rituximab in a more ��clinically relevant�� pre-clinical model, https://en.wikipedia.org/wiki/Chlormezanone functional assays were performed in tumour cells derived from patients with de novo or relapsed/refractory NHL. A total of eight lymph node samples were obtained from patients with various subtypes of B-cell lymphomas including follicular lymphoma (FL, n?=?3), diffuse large B-cell lymphoma (DLBCL, n?=?3), lymphocyte predominant Hodgkin lymphoma (HL, n?=?1) and Burkitt lymphoma (BL, n?=?1). Ofatumumab induced higher degree of cell lysis when compared to rituximab in four out of eight samples (P?