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0 for Windows, and a P-value http://www.selleckchem.com/products/Y-27632.html (n?=?7), if there were no suitable recipients (n?=?14), if the kidneys were considered too marginal to transplant (n?=?24) or not reported (n?=?10). Ten kidneys were transplanted outside the Eurotransplant region, data were missing of one transplanted kidney and one recipient died with an unknown graft function. Of the remaining 135 kidneys transplanted in the Eurotransplant region, 110 kidneys were machine perfused and 25 kidneys were stored on melting ice until transplantation (cold-storage). Donor, graft, and recipient characteristics are summarized http://www.selleck.cn/products/BKM-120.html in Table?1. Mean donor age was 45?��?16?years. The mean WITs and CITs were 26?��?11?min and 27?��?6?h, respectively. Donors and recipients predominantly comprised of men (73% and 68%, respectively). Of the transplanted kidneys, 30 recipients developed PNF (22%), 83 recipients DGF (62%), and 22 recipients IF (16%). Donor, graft, and recipient characteristics and their association with PNF are shown in Table?1. Only donor age was a significant risk factor for PNF in the univariate analysis (Table?1) and remained an independent risk factor for PNF in the multivariate analysis (Table?2). Further analysis of donor age, using the ROC-curve and its accompanying table (i.e. the point closest to the [1-1]-corner), showed the strongest association with PNF from an age of 54?years and older with an odds ratio of 2.857 (95% CI 1.242�C6.571; P?=?0.013). Kidneys from donors of 54?years and older have a higher percentage of PNF compared with younger donor kidneys (35% vs. 16%, P?=?0.012, respectively). The predictive value of donor age on PNF http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html was poor (AURC 0.640, 95% CI 0.553�C0.721). Adding the variables as used in the multivariate analysis to the model, the predictive value increased to ��fair�� (AURC 0.719, 95% CI 0.618�C0.805) (Fig.?1, Table?3). The median period of follow-up after transplantation was 6.5 (IQR 3.5�C12.2) years. Graft survival at 1 and 5?years after transplantation was 75% and 63%, respectively; kidneys with PNF included. Figure?2 shows graft survival, censored for recipient death with a functioning graft, of all transplanted kidneys (Fig.?2a) and functioning kidneys alone (Fig.?2b), with donor age categorized in groups. Graft survival of all transplanted kidneys was significantly lower for donor kidneys of 54?years and older, but graft survival of functioning kidneys was equivalent in both groups.