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Most patients spent most of the day sitting but reported no special way of sitting or lying. More than half of patients with SGD claimed no response to topical steroids and/or keratolytics. In comparison with patients with SGD, SGD-free patients were younger (61.3?��?36?years, P?=?0.0005) and heavier (BMI 26.2?��?15.6, P? http://www.selleckchem.com/products/CP-690550.html pressures and long hours sitting seemed to be important factors to trigger this dermatosis. Senile gluteal dermatosis (SGD) was first reported in Japan in 1979 as hyperkeratotic lichenified skin lesions of the gluteal cleft and seemed to be a common genital dermatosis, but there has been limited reporting in the West as well as minimal presence in major dermatology textbooks.[1-5] In addition to skin lesions on the gluteal cleft, as we pointed out recently in a study involving 12 patients with SGD, scaly brownish plaques may also occur on each side of the http://www.selleckchem.com/products/XL184.html buttocks and display a pattern of so-called ��three corners of a triangle��.[6] However, a large-scale clinical study of this disease is still lacking. It was difficult to recruit willing patients for examination as it required them to expose their gluteal area. We then opted to examine 162 consecutive outpatients who came to our OPD for their skin lesions on the gluteal area. SGD was defined as brownish scaly plaques on the gluteal cleft and each side of the buttocks forming complete or partial ��three corners of a triangle��. Patients with tinea, candidiasis, or cutaneous amyloidosis were excluded from the study. Patient's age, gender, body weight, the way they sit or lie on a chair or bed, and the response to the treatments were recorded. Fourteen skin biopsies were performed. Special attention was given to the types of chair or bed used by patients daily. Retrospective or concurrent patient chart review was performed to see if there was any significant association between SGD and underlying systemic illness. Relevant systemic diseases were arbitrarily defined as those that might have made patients more prone to long periods of sitting or lying, such as neurogenic disorders, malignant neoplasms, heart failure, chronic joint problems (spine or knee joints), http://www.selleck.cn/products/MLN8237.html and nutrition deficiencies. These diseases were included for analysis only if they had been present for at least five?years before SGD was identified with multiple hospitalizations or with occasional hospitalization but frequent outpatient visits for the same problem. For comparison of continuous and categorical variables between SGD and SGD-free groups, the independent t- test, Fisher's exact test, Odds ratio, and corresponding 95% confidence intervals were performed using IBM SPSS 19 (SPSS, Chicago, IL, USA). One-hundred and thirty-seven patients (85%) could be defined as SGD (Fig.