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In the commercialised version (Impact-R?; Matis Medicals Inc, Beersel, Belgium), a polystyrene surface is used. The surface induces platelet adhesion and subsequent secretion and aggregation. Afterwards, bound platelets are stained and measured using an image analyser. The result is given as the percentage of surface covered with stained platelets and the average size of the platelet aggregates retained [69]. A positive correlation exists between platelet count and surface coverage or average size of platelet aggregate [63, 69]. An exception is that average size of platelet aggregate was found not to correlate with platelet count in patients with ITP [63]. The process is automated and provides http://www.selleck.cn/products/nlg919.html a result within 6?min. It is easy to perform and requires only a small quantity of blood [47]. Clinical utility: The Cone-and-Plate[let] analyser performs an overall evaluation of the platelet adhesion and subsequent secretion and aggregation process. The test result is unspecific and cannot be used for direct diagnostic purposes. Overall, the clinical applicability http://www.selleckchem.com/products/pexidartinib-plx3397.html of the method has only been sparsely investigated. The surface coverage is found to be decreased in patients with known Bernard�CSoulier syndrome [70], Glanzmann's thrombasthenia [69] or platelet secretion defects [71]. Increased surface coverage is seen in patients with thrombotic thrombocytopenic purpura [72]. Without regarding the platelet count, the analyser has shown high predictive value for excluding a bleeding disorder in one study http://www.selleckchem.com/products/bmn-673.html [73]. Moreover, Kenet et?al. [74] studied 42 thrombocytopenic patients from a haematological department. They found that patients with bleeding symptoms had lower percentage of surface coverage and lower average size of aggregates compared with patients without bleeding symptoms. Bleeders also had lower platelet count and MPV. When taken together, 95% (21/22) of patients with low surface coverage (