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90 (95% CI: 0.35�C2.32; P = 0.82). Two studies compared specificity of detecting lesions (83, 87), yielding an OR http://www.selleck.cn/products/CAL-101.html of 0.26 (95% CI: 0.14�C0.51; P http://www.selleckchem.com/products/gsk2126458.html Per-patient specificity was analyzed in four studies (67, 70, 71, 76). There was no evidence of difference between procedures (OR: 0.36; 95% CI: 0.09�C1.49; P = 0.16). Two studies compared specificity of detecting lesions (87, 89), yielding an OR of 0.31 (95% CI: 0.10�C1.00; P = 0.05), with high inconsistency among study results (P = 0.02; I2 = 80.1%). Using a random-effect model the statistical significance was not confirmed (OR 1.36; 95% CI: 0.76�C2.43; P = 0.29). Only one study (87) provided data for comparison of per-patient sensitivity, while two studies (78, 87) contributed information for per-lesion analysis, showing a statistically significant result in favor of MRI (OR: 2.65; 95% CI: 1.26�C5.57; P = 0.01), but heterogeneity was detected (P = 0.05; I2 = 74.3%). Using a random-effect model, the statistical significance was not reached (OR: 1.77; 95% CI: 0.29�C10.61; P = 0.53). No study analyzed per-patient specificity, while http://www.selleckchem.com/products/bay-57-1293.html one study (87) used a per-lesion approach. Treatment of CRC liver metastases has been characterized by remarkable advances over the past 15 years. Thus, the imaging technique able to demonstrate the exact number, localization, and size of metastases is crucial to determine resectability (91). Although in the past 10 years a variety of modern imaging tools have been used to diagnose focal liver lesions, the optimal imaging staging strategy has not yet been defined. This review was aimed at establishing evidences of diagnostic performance of US, CT, MRI, and FDG-PET for the detection of liver metastases.