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The published data suggest that the use of core biopsy has significantly increased the preoperative diagnosis rate in screen-detected breast cancers.2�C4 The majority of NCB are classified as normal (B1), benign (B2) or malignant (B5).5 The accuracy of benign and malignant NCB diagnoses is supported through the use of two borderline categorizations; lesion of uncertain malignant potential (B3) and suspicious of malignancy (B4). The B3 category consists of a heterogeneous http://www.selleckchem.com/products/ly2157299.html group of lesions which may yield only benign histology on initial NCB sampling but are recognized to show heterogeneity and may harbor malignancy elsewhere or to have an increased risk of associated adjacent malignancy.5, 6 Although the B3 category constitutes a relatively small proportion of all NCB (3�C9%; average 6%4, 7�C12), most cases progress to surgical intervention to establish an excision histology diagnosis. This has significant implications particularly in screen-detected (nonsymptomatic) breast lesions in which final benign diagnoses after surgical intervention is a drawback of mammographic screening. In a previous study, we reported the positive predictive value (PPV) of B3 diagnosis of screen-detected http://www.selleckchem.com/products/z-vad-fmk.html mammographic abnormalities from the Trent region, UK (523 subjects).13 In our study, we aimed to assess the outcome of screen-detected lesions diagnosed as B3 category on routine practice in a large series of cases to validate http://www.selleck.cn/products/XL184.html and confirm our previous findings. One key goal of our study was to attempt to characterize the malignant lesions diagnosed after B3 in routine breast screening practice. For this reason we chose to concentrate on cases where subsequent surgical biopsy was performed allowing accurate final diagnostic classification. This was a retrospective study of all women who attended one of the seventeen breast screening units in the West Midlands and South Central regions, UK from 1st of April 1999 until 31st of March 2006. Women aged 50�C70 are invited for screening by two view mammography without breast examination every 3 years. The reason for performing NCB was usually the presence of a mammographic abnormality which was not definitively benign. A small proportion of NCB (