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An overall ANOVA with a level of significance of 5% was then used to compare the means of the transmural angles between these 36 sub-components. In those instances shown to be statistically significant, we then performed similar ANOVAs to test differences within each of the 12 designated mural segments. Stata? 8.0? 1984�C2003 Statistics/Data Analysis package (Stata Corporation, 4905 Lakeway Drive, College Station, TX) was used for statistical analysis of data. All animal experiments were conducted after approval from the Danish Inspectorate of Animal Experimentation. The guidelines from this institution comply with ��NIH publication No. 86-23, regarding http://www.selleckchem.com/products/Adrucil(Fluorouracil).html principles of laboratory animal care (revised 1985). The authors had full access to the data and take responsibility for its integrity. All authors have read http://www.selleckchem.com/products/SRT1720.html and agree to the manuscript as written. The random scatter-plots shown in Figures 3-5 depict the transmural angles of the aggregated chains of cardiomyocytes as a function of their mural depth in the 12 predetermined left ventricular mural regions. Specifically, Figure 3 shows the transmural angles in the basal regions, Figure 4 shows the angles in the equatorial regions, and Figure 5 shows the angles in the apical regions. For clarity, we have also listed the mean transmural angles (Table 1). As shown in the figures and in the table, there are great differences between the regional distributions, as well as within the transmural subcomponents. This is reflected in the analysis of the mean transmural angles. The overall MANOVA, with P? http://en.wikipedia.org/wiki/MERTK the posterior apical wall (P