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Age, prostate volume and Gleason grade did not show any effect on f/t PSA. Conclusions:?In men with LUTS the specificity of various f/t PSA ratio cut offs; described for population based screening, is too low to be used as an aid to defer http://www.selleckchem.com/products/Fludarabine(Fludara).html the decision of biopsy in PSA ranges of 4�C10 and 4�C20. 259 Geographical variation in renal cell carcinoma; is it still a disease of elderly? S. AGNIHOTRI, M. JAIN, R. KAPOOR and A. MANDHANI Sanjay Gandhi postgraduate Institute of Medical Sciences, Lucknow, India Introduction:?To study the spectrum of renal cell carcinomas (RCC) in India with regards to age of onset, stage at presentation and survival. Patients and Methods:?Patients with renal tumor, treated from January 2000 to December 2012 were analyzed for age at presentation, clinical features and histopathological characteristics. Clinical diagnosis https://en.wikipedia.org/wiki/Chlormezanone was made by contrast enhance computerized tomography (CECT) scans and or MRI. Renal masses diagnosed as Angiomyolipoma, infective masses and hydatid cysts were excluded from the analysis. Impact of various age groups on gender, tumor size, TNM stage, Fuhrman grade, histopathological subtypes, lymph node, inferior vena cava (IVC) involvement and survival was analyzed. Patients were grouped in 5 age groups i.e. ��39, 40�C49, 50�C59, 60�C69 and more than 70 years of age. Results:?Of total 617 renal tumors in 617 patients (2 patients had bilateral tumors but only the larger tumor was considered), clinically suspected as RCC, 586 had epithelial cell tumor and rest of the 31 had non epithelial cell tumor. The mean http://www.selleckchem.com/products/Nolvadex.html tumor size was 8.08?��?3.5?cm (median 7, range 1�C25?cm). Tumor of less than 4?cm size was present in only 10.4% of the patients. The mean age at diagnosis was 55.15?��?13.34 (median 56, range 14�C91 years) years. 30.03% of renal tumors presented in patients younger than 50 years of age. Though there was no difference in stage, Fuhrman's grade, IVC involvement and lymph nodal spread among various age groups, younger patients had higher proportion of non clear cell RCC and only 48.59% of them presented with conventional RCC. Mean survival was lower in patients younger than 39 years with HR of 1.7 (0.8�C3.2) Conclusions:?Renal cell carcinoma is more frequent in younger people in India. One third of the patients were less than 50 years of age and only 10.4% of the patients had tumor of less than 4?cm (Ta). Younger patients of