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These are the main predictor variables in the tools being compared and this suggests that the comparison is robust. The PCCOD represents a realistic reflection of South Australian, and possibly Australian, RPs. It is therefore reassuring that the concordance of internationally derived risk prediction tools remains high in this Australian cohort. However, if poorly calibrated, the high concordance of the tools is likely to be of little comfort to a physician or the patient being counselled. Our findings support the need for the validation http://www.selleckchem.com/products/CHIR-99021.html of tools developed in different populations and, if necessary, their recalibration to adjust for the differences in uncaptured risk modifying characteristics of the local population. We thank the members of the South Australian Prostate Cancer Clinical Outcomes Collaborative for their support of the study. None declared. ""Study Type �C Therapy (case series) Level of Evidence?4 What��s known on the subject? http://www.selleckchem.com/products/LY294002.html and What does the study add? Robotic prostatectomy has now become the most common surgical approach in the United States for patients with prostate cancer. There is a significant learning curve for this procedure and this paper attempts to help understand what factors will make the operative times longer. Very little to date has been written on this topic. To determine risk factors for prolonged operative time (OT) during robot-assisted laparoscopic radical prostatectomy (RALP). Being able to predict prolonged OT is of pivotal importance both to the physician for patient counseling and to the hospital management. Retrospective review of patient records undergoing RALP between 2003 and 2009 at a tertiary academic center with a structured teaching program. The following variables http://www.selleck.cn/products/wortmannin.html were recorded: age, race, body-mass index (BMI), previous abdominal surgery (yes/no), nerve-sparing technique (yes/no), lymph nodes dissection (yes/no), pathological stage (organ-confined versus non), cumulative surgical experience with RALP (expressed as number of years since introduction of RALP at our center), prostate weight and OT calculated skin-to-skin by the anesthesiologists. Prolonged OT was defined as the upper quintile (20%) according to the distribution. Multivariate regression model was generated to assess potential predictors of prolonged OT. A total of 523 records were retrieved. Caucasians accounted for 77.8% of the cohort. Median age was 60.3 years (interquartile range, IQR, 55.0�C64.6 years), median BMI 28.1 (25.8�C30.7?kg/m2), prostate weight 46.0?g (37.0�C57.8?g). Eighty-six (16.4%) patients had previous abdominal surgery, lymph nodes dissection was performed in 341 (65.2%) and nerve-sparing technique was done in 310 (59.3%) cases. Median OT was 175?min (IQR 146�C220?min). Prolonged OT was set at >230?min, thereby 105 (20.1%) records were classified as such. On multivariate analysis, cumulative surgical experience with RALP (P