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Together with anthropometry and PFA evaluation, the use of the DQI-I would add prognostic value to both the initial growth assessment and the patients�� growth monitoring. ""Aims:? To evaluate outcome in the first generation of children with end-stage heart disease to whom heart transplantation was available. Methods:? Retrospective review of all 135 Swedish children http://www.selleckchem.com/products/pf-562271.html were omitted from outcome analysis). Results:? Waiting-list mortality was 31% http://www.selleckchem.com/products/VX-765.html (44% in infants). Median waiting time in 82 transplanted patients was 57?days (0�C585?days). Post-transplant follow-up time was median 5.9?years (0.03�C20.1?years), and actuarial survival was 92% at 1?year, 82% at 5?years, 76% at 10?years and 58% at 15?years. Survival after listing was 64% at 1?year, 58% at 5?years, 52% at 10?years and 40% at 15?years. Post-transplant complications included rejections (34%), malignancies (12%), renal failure (8%), coronary artery vasculopathy (6%) and re-transplantation (5%). Among 64 survivors, 84% were free of complications affecting prognosis. Conclusion:? High waiting-list mortality and post-transplant attrition precluded 60% of this pioneer population from reaching adulthood. Functional status in survivors is generally good. ""Aim:? To assess the effect of beta-blockade therapy on progressive aortic dilatation and on clinical outcome in children and adolescents with Marfan��s syndrome (MFS). Methods:? The meta-analysis was instituted, which included studies identified by a systematic review of MEDLINE of peer-reviewed publications. Echocardiogram measurements of the aortic root dimension and outcome measures of mortality and major morbidity were compared between patients who were treated and untreated with beta-blockade therapy. http://www.selleck.cn/products/azd6738.html Results:? Five studies were included. A total of 224 young patients treated with beta-blocker therapy and 168 patients did not accept medical management. Compared with non-beta-blockade treatment, beta-blockade therapy significantly decreased the rate of aortic dilatation (SMD?=??1.30 with 95% CI ?2.11 to ?0.49). A tendency of clinical outcome beneficial was observed in the beta-blocker treatment group when compared with no beta-blocker treatment group (odds ratio?=?0.87 with 95% CI 0.37�C2.04). Conclusion:? There is evidence that beta-blockade therapy can slow down the rate of dilatation of the aorta and has clinical benefits on children and adolescents with MFS. ""To examine health-related quality of life (HRQOL) in children and adolescents with type 1 diabetes on intensive insulin treatment.