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Bone age (BA) was determined by a single blinded observer using a left hand-wrist radiograph according to Greulich and Pyle standards [10]. Hypothalamus�Cpituitary MRI was performed using a 3.0 T Scanner (Siemens, Erlangen, Germany) in the sagittal and coronal planes on T1- and T2-weighted images. The slice thickness was 3?mm. The height of pituitary gland was measured and contrast-enhanced MRI of the hyperplastic pituitary was performed. Imaging parameters for the uterus and ovaries were as follows: uterine volume (UV), ovarian volume (OV) and follicular diameter (FD), which were all obtained by transabdominal pelvic sonography using a 3.5-MHz transducer (LOGIQ 9 system, GE healthcare, Milwaukee, WI, USA). An ovarian cyst was defined as a follicular structure larger than 20?mm. All measurements were carried out by the same trained sonographer. Normally distributed variables were expressed as means?��?standard deviation (SD). Skewed distributed variables were expressed http://www.selleck.cn/products/azd6738.html as median (interquartile range). Comparisons between group A and group B were analysed using the independent sample t-test for parametric variables and using the Mann�CWhitney U-test for nonparametric variables. Categorical variables were compared by chi-squared test. Paired data before and after treatment were analysed with parametric test (paired t-test) and nonparametric test (Wilcoxon signed ranks test). Pearson correlations were used for parametric variables, and Spearman correlations were used for nonparametric variables. A two-tailed p-value http://www.selleckchem.com/products/pf-562271.html statistically significant. Statistical analyses were carried out using standard computer software SPSS version 17.0 (SPSS Inc., Chicago, IL, USA). At study entry, all girls showed typical symptoms and signs of hypothyroidism (Table?1). MRI scans showed marked homogeneously enlarged pituitary gland with suprasellar extension. There were no neurological symptoms such as headache in the girls. In group A, http://www.selleckchem.com/products/VX-765.html the age at onset of hypothyroidism was 1.5 (0.0, 5.4)?years. The duration of clinical signs and symptoms was 8.3 (1.8, 10.0)?years. No patient met the criteria for a pubertal activation of the HPG axis. Six girls had one or more episodes of vaginal bleeding. Two girls had isolated breast development without any other signs of sexual maturation. No girl was presented with galactorrhoea and pubic hair. Pelvic ultrasound imaging showed bilateral multicystic ovaries. Ovarian cysts were found in patient 1 and patient 3 (Table?2). In patient 1, the initial chief complaints were abdominal pain and vaginal bleeding. She was diagnosed with a large left ovarian cyst by local hospital and underwent removal of the cyst. The histopathology showed haemorrhage and myxoedematous infiltration within the benign cyst. Ovarian cyst reappeared within few months, so she was referred to our department. Girls in group B were all at the prepubertal stage. The age at onset of hypothyroidism was 1.3 (0.0, 7.