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Feasibility of blinding examiner was considered as possible in 187 RCTs (68%). Examiner was not blind in 106 studies (38%) and no information was provided in 91 (33%), whereas in the residual 79 RCTs (29%) blinding of examiner was reported. When considering only studies where blinding of the examiner was feasible, operator was rated blind in 79 on 187 RCTs, corresponding to 42% of the subgroup sample. No drop-out or presence of drop-out with a clear explanation was reported in 182 RCTs (66%), whereas 79 (29%) reported no information and 15 (5%) reported drop-outs http://www.selleckchem.com/products/GDC-0941.html with no explanation. Generally, all outcome variables reported in 'Material and Methods' section were reported in 'Results' section (99%). Selective data reporting was detected only in two RCTs while http://www.selleckchem.com/products/AZD0530.html the protocol was published for only two studies. The length of the follow-up was rated as clear in 242 (88%) RCTs, reported but unclear in 33 studies (12%) and not reported in one RCT. The median follow-up period was 12?months (first quartile 6?months and third quartile 36?months) [minimum 0 and maximum 192?months]. Generally, information concerning operator/institution experience for the experimental procedure was poor. No information concerning operator experience was reported in 219 RCTs (79%); similarly no information concerning institution experience was reported in 270 RCTs (98%). The majority of RCTs (190 studies corresponding to 69%) did not report patient-centred outcomes by questionnaire while the residual 86 RCTs (31%) showed patient-related outcomes. Assessed RCTs reported a statistically significant difference between the treatments for the primary outcome variables in 91 studies (33%), whereas 185 (67%) reported no significant difference between the treatments. Bivariate logistic regressions using ��year of publication�� as explicative variable and quality items as outcomes variables (Table?7) showed that an increased number of RCTs http://en.wikipedia.org/wiki/Diglyceride in Europe compared with America (p?=?0.0050) and a reduction of funding from both private and public institution (p?=?0.0029) during time. An increase of RCTs with random sequence generation at low risk of bias (p?