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[1] Table?2 shows measurements obtained during CPET. All but five patients showed reduced maximum exercise capacity (peak VO2 below 84% predicted),[14] and 22 (41%) showed ventilatory limitation to exercise at least as defined as increased peak minute ventilation (VE)/MVV ratio (>0.85).[14] The majority of patients (46/54; 85%) showed DH as previously defined, that is, any reduction in IC from rest to peak exercise. The profile of chronic bronchitis or frequent exacerbations was not associated with the presence of DH (P?>?0.05). IC at peak exercise were significantly (P? http://www.selleckchem.com/products/Dasatinib.html rest (r?=?0.76), FEV1 (r?=?0.78), FVC (r?=?0.59), FFM (r?=?0.38) and FFM index (r?=?0.29; Fig.?2). Body mass index (BMI) was not associated with rest or peak IC (P?=?0.64 and 0.80, respectively). No correlation was found between FFM index and parameters of resting hyperinflation (resting IC), airflow obstruction (FEV1) (Fig.?3) and IC change from rest to peak exercise (r?=?0.13; P?=?0.35). Additionally, similar FFM index was found comparing patients with different COPD stages (P?=?0.71), and the proportion of FFM depleted and non-depleted patients was similar across COPD stages (P?=?0.98). VO2 at non-invasively determined http://www.selleckchem.com/screening/epigenetics-compound-library.html AT was obtained in 42/54 (78%) patients and was associated (P? https://en.wikipedia.org/wiki/Evodiamine considering resting lung function or exercise measurements. Our data showed that the greater the FFM index the greater the peak IC is, suggesting lower DH and lower operational lung volumes at peak exercise. This may reflect the worsening of nutritional status that accompanies the severity of the disease because a greater proportion of low FFM index patients is observed with advancing disease.[19, 20] Although resting lung function measurements were not associated with FFM index (Fig.?3), in a linear multivariable analysis to predict peak IC, only FEV1 and rest IC remained in the model. Therefore, the hypothesis that lower FFM index would independently result in higher pulmonary hyperinflation (lower peak IC values) was not confirmed.