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001). MD was associated with disability in the ADLs [odds ratio (OR)=2.40, 95% confidence interval (CI)=1.05�C5.51], and IADLs (OR=2.77, 95% CI=1.07�C7.16) in logistic regression, after adjusting. The association of MD with disability was stronger among subjects aged 80+. Conclusions: MD is independently associated with disability in community-dwelling elderly. Further studies are needed to evaluate the impact of early detection and correction of MD on the preservation of functional status in older populations. ""The purpose of this study was to elucidate whether the association between beta-3 adrenergic receptor polymorphism and periodontal disease is modified by body weight. We enrolled 332 postmenopausal women and determined http://www.selleckchem.com/screening/tyrosine-kinase-inhibitor-library.html their HbA1C levels (%) and beta-3 adrenergic receptor (rs4994) genotypes. Periodontal parameters including clinical attachment level (CAL) were measured. After selecting subjects for each body mass index (BMI) level, the prevalence rate ratio (PRR) by multiple Poisson regression analysis was calculated to evaluate the relationship between periodontal disease and beta-3 adrenergic http://en.wikipedia.org/wiki/VAV2 receptor polymorphism. The number of sites with CAL��6?mm was used as a dependent variable, and beta-3 adrenergic receptor genotype [categorized as Arg non-carriers (reference) or Arg carriers], age (y) and HbA1C (%) were adopted as independent variables. We converted the number of probing sites (n) to an offset variable. The PRR of the beta-3 adrenergic receptor genotype for the number of sites of CAL��6?mm showed a positive association in subjects with BMI��25.0 and increased markedly with BMI. The PRR in subjects with BMI��30 was 3.10 (p? http://www.selleckchem.com/GSK-3.html selected. Dietary vitamin C intake was assessed by a self-administered dietary record. Fasting blood samples were obtained and analysed for vitamin C concentrations in plasma, PMNs and PBMCs by means of high-pressure liquid chromatography (HPLC). Plasma vitamin C was lower in periodontitis patients compared with controls (8.3 and 11.3?mg/l, respectively, p?=?0.03). Only in the control group a positive correlation was present between vitamin C intake and plasma values. No differences could be assessed between patients and controls regarding vitamin C dietary intake and levels in PMNs and PBMCs. In the patient group, pocket depth appeared to be negatively associated with the vitamin C concentration in PMNs.