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The main acquisition parameters were as follows: field of view 42?��?42?cm, acquisition matrix 256?��?192, half Fourier space, and number of excitations equal to one. Images were obtained at the same phase of the cardiac cycle aiming for mid-diastole on sequential heart beats using prospective ECG gating. Each image was recorded during an end-expiratory breath-hold of no more than fifteen seconds. All http://www.selleckchem.com/products/Adriamycin.html postprocessing computations were performed with a dedicated software developed with MATLAB (The Math Works Inc., Natick, MA, USA). At first, studies were anonymously submitted to one senior observer (JME) experienced in cardiac MRI and blinded to all patient data. Successive images obtained for each TE were corrected for heart displacement (translation and rotation) using an automatic feature-based image registration technique. The registration consisted in minimizing the distance between features extracted from each image by a Sobel edge detector using gradient descent optimization. The registration could be assessed by the observer through a movie presenting the ten images in a loop. When necessary, a manual correction of heart displacement was subsequently carried out. Thereafter, two regions of interest (ROI) were drawn by the observer covering the septum of one image and corresponding to the anteroseptal and inferoseptal segments http://www.selleckchem.com/products/obeticholic-acid.html according to AHA recommendations [20]. These two ROI were copied/pasted onto each image of the multiple TE series. Inferior, anterior, and lateral walls were not analyzed in this study, as previously described, to avoid the confusing influence of signal from surrounding fat [11]. An example of the positioning of these ROI is provided in Fig.?1a. T2 calculations were performed for each ROI with a nonlinear two-parameter Levenberg�CMarquardt exponential fit applied to the myocardial signal measured on the echo images and based upon the equation , TE being the specific effective echo time obtained during acquisition and M(TE) the myocardial signal. Examples http://www.selleck.cn/products/LY294002.html of this fit are presented in Fig.?1b. Confidence intervals for T2 measurements and r2 values were computed from the exponential fit. Segments with r2?