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As highlighted earlier, the low participation rates means that our participants could be described as a ��self-selected sample��. This is a limitation of this research and the conclusions drawn here should be considered with this in mind. The authors are members of EyeNET, http://en.wikipedia.org/wiki/MRIP the primary care eye research network supported by the Department of Health. The present work was funded in part by EyeNET, and also by the Association of Optometrists, Royal National Institute of Blind People (RNIB), Central (LOC) Fund, the American Academy of Optometry (British Chapter), and the College of Optometrists. The views expressed in this publication are those of the authors and not necessarily those of any of the funding organisations. The funding sources had no role in the design, conduct, or reporting of the study or in the decision to submit the manuscript for publication. The researchers had open and full access to all the data files for the study and had full control over the data. ""This study examined the effect of myopic defocus on visual acuity (VA) over time, with attention being paid to the first point at which blur adaptation had a significant and measurable effect on defocused VA. Visual acuity was sampled at a higher rate than previous studies in order to assess the time course of blur adaptation processes in myopic and emmetropic observers. Participants were 24 normally-sighted observers (12 emmetropes and 12 myopes, median age: 22.5?years). All ametropic participants wore their full refractive correction throughout the experiment. 1 D and 3 D http://www.selleckchem.com/products/AZD1152-HQPA.html of myopic defocus were introduced in two separate, randomised sessions. Visual acuity was measured using Test Chart 2000 at 2?min intervals http://www.selleckchem.com/products/pf-06463922.html over a 30?min session whilst looking through defocus lenses. Recovery clear VA was also measured every 2?min for a further 20?min. Defocused VA was found to improve significantly within 4?min after the introduction of defocus for both 1 D (P?