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5?kg/m2 leads to poorer outcomes. In the studied population of transplant recipients, obesity has no clear negative impact on post-transplant survival, and appears even protective in male recipients with BMIs between 25 and 35?kg/m2. These observations provide new insights to the debate of liver transplant candidates' weight management. In fact, a protective effect of overweight has never been described in liver transplantation so far, and to the best of our knowledge, this http://www.selleckchem.com/products/Everolimus(RAD001).html is the first study providing a dynamic analysis of wait list BMI variations. Underweight has been repeatedly shown to be a marker of poor prognosis after liver transplantation [9, 12, 16, 17], and this association has been confirmed herein. Our study went one step further, analysing the adjusted impact of http://www.selleck.cn/products/Bortezomib.html wait list BMI changes on survival after liver transplantation. It showed a trend towards poorer survivals in patients with decreasing BMIs http://www.selleckchem.com/products/PD-0332991.html effect of candidate obesity after liver transplantation has been investigated on several occasions [7-12]. Some studies have observed increased rates of early postoperative complication and death, longer hospital stay and higher cost, but an acceptable long-term survival [8, 21]. Other studies have demonstrated an improved survival benefit, compared with obese patients remaining on the list [9, 11]. In this study of highly selected liver transplant candidates, obesity had no clear impact on post-transplant outcome, and high BMI should not be seen as a formal contraindication for liver transplantation. Our findings even suggest that after allowing for confounding factors, liver transplant recipients benefit from moderate body-weight excess (BMI 25�C35?kg/m2), as reflected by the lower covariate-adjusted HR for death in overweight and grade 1 obese male patients.