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Popliteal artery wall thickness, knee cartilage volume and bone marrow lesions (BML) were assessed. Results: Of 278 participants with valid popliteal artery wall thickness measurement, 254 (91.4%) completed 2-year follow-up. After adjusting for age, gender, body mass index and tibial bone area, increased popliteal artery wall thickness was associated with reduced medial tibial cartilage volume (B = -6.7, 95% CI -12.9, -0.6, p=0.03) and increased rate of medial tibial cartilage volume loss (B=0.06, 95% CI 0.01, 0.12, p=0.03). There was a trend for medial tibiofemoral BML worsening in relation to increased popliteal artery wall thickness (odds ratio=1.07, 95% CI 0.99, 1.15, p=0.07). No significant associations were observed in lateral tibiofemoral compartment. Conclusion: Increased popliteal artery wall thickness was associated with adverse changes in knee structure, as evidenced by reduced medial tibial cartilage http://www.selleckchem.com/products/Y-27632.html volume, http://www.selleck.cn/products/BKM-120.html increased rate of cartilage volume loss and a trend for BML worsening over 2 years. These findings suggest an association between vascular pathology and early knee structural changes, supporting the hypothesis that vascular health may play a role in the development of knee osteoarthritis. ? 2014 American College of Rheumatology. ""Studies assessing the prevalence of anti�CRNA polymerase III (anti�CRNAP III) antibodies in systemic sclerosis (SSc) have yielded a wide range of results. The aim of the present study was to describe a new SSc cohort tested for presence of anti�CRNAP III and perform a systematic review and meta-analysis to assess the prevalence of anti�CRNAP III in patients worldwide and the potential factors of variability. Seropositivity for anti�CRNAP III was evaluated in a French cohort of SSc patients. A systematic review of the literature was carried out in PubMed and EMBase. Meta-analysis was performed using available data on prevalence, clinical characteristics of SSc patients, and the types of assays used for anti�CRNAP III testing. One hundred thirty-three French SSc patients were tested for anti�CRNAP III, and a prevalence of 6�C9% was found in these patients. Thirty studies representing a total population of 8,437 SSc patients were included in http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html the meta-analysis. Prevalence of anti�CRNAP III in this population was highly variable (range 0�C41%). The overall pooled prevalence of anti�CRNAP III was 11% (95% confidence interval 8�C14), but heterogeneity was high among studies (I2 = 93%, P