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All confounders were suitably categorized and missing values were considered as a separate category. All listed confounders had a significant influence on DWFG in univariate analysis and were therefore included in the multivariable Cox regression model. With the exception of pretransplant CMV status and steroid use, all factors had a significant influence in the multivariable Cox model. http://www.selleckchem.com/products/AC-220.html Cox analysis was stratified according to the patient's geographical origin. For cumulative incidence of DWFG, we calculated hazard ratios (HRs) of confounders with 95% confidence interval (CI). Hospitalization http://www.selleckchem.com/products/nutlin-3a.html during first posttransplant year was recorded at the time of 1-year follow-up for patients with a functioning graft at 1 year. Frequency of repeated hospitalizations or length or severity of infection were not considered in the analysis. Association of HLA class I and II mismatch with hospitalization was tested using logistic regression considering the same confounders as considered in analysis of DWFG and, in addition, considered geographical region as a confounder. P values below 0.05 were considered significant. The software package IBM SPSS Statistics version 20 was used. In total, data from 177 584 kidney transplants were analyzed. Patient demographics and baseline characteristics are shown in Table 1. During the first posttransplant year, 7926 patients were reported to have died with a functioning graft, and a further 8855 patients were reported to have died with a functioning graft during the years 2�C5. The incidence http://www.selleck.cn/products/Romidepsin-FK228.html of DWFG during the first posttransplant year (Kaplan�CMeier estimation) was 4.8% (SE 0.05%), and 7.7% (SE 0.08%) during posttransplant years 2�C5 (approximately 2% per year). Causes of DWFG differed during year 1 and years 2�C5 (p