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A majority of men in both groups were Caucasian (98%), with 1% of participants being http://www.selleck.cn/products/s-gsk1349572.html African American and 1% multiracial/other. Men with and without T2DM were similar in age, height, and tibia and radius length (Table 1). As expected, those with T2DM were heavier (+6.2?kg, p? http://www.selleckchem.com/products/ly2157299.html the men with T2DM were taking statins compared with slightly less than half the men without T2DM. As reported previously for the whole MrOS cohort,24 men with diabetes had significantly higher aBMD measured by DXA at all measured sites (+4% to +8%, p? http://www.selleckchem.com/products/z-vad-fmk.html significant for density before weight adjustments (p?=?.025) and for total area after adjusting for weight (p?=?.007). The slightly greater density in diabetics compensated for lower bone area, so there was no difference in estimates of compressive bone strength (BSI) between groups at this site after adjusting for body weight (p?=?.591, model 2; see Table 2). Participants with diabetes also tended to have smaller total bone area (?1% to ?2%) at the cortical 66% site of the tibia, which was significantly different only after adjusting for body weight (p?=?.031). Cortical area was similar between groups both before and after adjusting for body weight. Cortical bone density was not different between groups at this site in either model. The smaller total bone area translated to a lower bone bending strength (section modulus, ?2.8%, p?=?.033) after adjusting for body weight. SSIp also tended to be lower in men with diabetes after adjusting for body weight (?2.5%) but was not significantly different (p?=?.106). Prior to adjusting for body weight, however, there was no difference in section modulus (p?=?.819) or SSIp between groups (p?=?.636). Diabetic participants also had significantly larger muscle CSA (model 1, p?=?.002), although the muscle size was appropriate for their higher body weight (model 2, p?=?.841). Bone parameters at the radius followed a similar pattern as those at the tibia (Table 3).