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CBC, biochemical panel, and urinalyses were within reference intervals, except for subclinical thrombocytopenia in 2 dogs. Prednisone dosages (calculated as 50?mg/m2/day) ranged from 0.96 to 2.27?mg/kg/day as administered, with the lowest per kg dosages given to the 2 Great Danes. All dogs improved clinically over the 4-week course of the study, and no dogs were given azathioprine rescue. Eight of 9 dogs had increased serum alkaline phosphatase (ALP) activities by week 2. Thrombocytopenia resolved in both affected dogs by weeks 2�C4. Median CBPI scores for each of 11 questions improved significantly in all dogs at weeks 2 and 4 compared with baseline (P?=?.0017; Fig?1A). Mobility as measured by accelerometry was significantly greater at week 4 compared with baseline (P?=?.0024; Fig?1B). One dog http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html (SB) did not wear the collar consistently, and had a cruciate ligament rupture newly diagnosed at week 4 of prednisone treatment. This dog's accelerometry and 4-week CBPI scores were not included in data analyses. The number of joints per dog with total nucleated cell counts >3000/��L decreased significantly between baseline and week 2 (P?=?.008; Table?1). The number of joints with >12% neutrophils or with moderate-to-severe inflammation varied among dogs, and was not significantly different over time (Table?1). Baseline plasma concentrations of CRP were significantly higher http://www.selleck.cn/products/BKM-120.html in dogs with IMPA (median 91.1?��g/mL, range 76.7�C195.0) compared with healthy controls (3,000 nucleated http://www.selleckchem.com/products/Y-27632.html cells/��L; r?=?0.49, P?=?.011) and a modest inverse correlation with mobility as measured by accelerometry (r?=??0.42, P?=?.048). Plasma IL-6 concentrations were also significantly increased in IMPA dogs before treatment (median 45.9?pg/mL, range 28.6�C871.5), compared with healthy controls (median