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Cases and controls were matched on the year of investigation to minimise possible diagnostic trends. Enzymatic methods were applied to measure http://www.selleckchem.com/products/Fludarabine(Fludara).html fasting serum lipid profiles using a Hitachi 7600 automatic clinical chemistry analyser (Boehringer Mannheim, Mannheim, Germany) and reagent kits supplied by the manufacturer at both hospitals. All data on age, gender, family history of RCC, history of hypertension or diabetes, body mass index (BMI), smoking status, alcohol consumption, lipid profiles, statin usage, histology, and stage at diagnosis (TNM classification) were obtained from electronic records and medical charts. Protocols were approved by the Institutional Research Review Boards of Fudan University Shanghai Cancer Center and the Affiliated Hospital of Medical College, Qingdao University. Written informed consent was obtained from all participants before participation in the study. Risk factor definitions were: (i) http://www.selleckchem.com/products/Nolvadex.html the threshold of hypertension was set at 140 and 90?mmHg for systolic and diastolic blood pressure, respectively, on three consecutive occasions; (iii) diabetes was based on either one of the following criteria: fasting serum glucose level of ��7.0?mmol/L, normal fasting serum glucose level owing to usage of anti-diabetic medication, or self-report of a physician's diagnosis of diabetes; (iii) BMI was defined as the first reported weight (in kilograms) divided by height in square meters, and a BMI of ��25?kg/m2 was considered as overweight; (iv) smoking status (yes/no) meant current smokers or those who had ever smoked at least 100 cigarettes per year; (v) alcohol consumption (yes/no) indicated an average daily alcohol intake of >25?g alcohol for at least 1 year [12]. Lipid profiles were stratified in accordance with the Chinese https://en.wikipedia.org/wiki/Chlormezanone Guidelines on Adult Dyslipidaemias (Version 2007). Statin usage denoted patients who were using or had ever used some kind of synthetic statin (atorvastatin, simvastatin, fluvastatin, lovastatin, rosuvastatin, pravastatin or Xuezhikang capsules whose essential component is lovastatin). Chi-squared tests were used to compare differences in categorical variables, and Student's t-tests were used for continuous variables. Kendall's �� tests were used for trends in lipid profile rankings. Unconditional multiple logistic regression was used to estimate odds ratios (ORs) and 95% CIs, including previously identified clinical variables, e.g. age, gender, history of hypertension or diabetes, BMI and smoking status. The P values were two-sided for all statistical tests. A P