Advances in Inflammatory Bowel DiseaseWhat's New, What's Next
The complete workgroup reports are available for direct download at http://links.lww.com/IBD/A77 . Experts Outline New Agenda for IBD Research Based on a thorough review in each area, the workgroups have defined key research priorities for the next few years, including: Defining clinically relevant subgroups of IBD patientsusing different types of information to predict aggressiveness of disease, complications, and response to treatment. Understanding the environmental factors affecting the risk and course of IBDincluding environmental "triggers" and a specific focus on the role of diet. Clarifying the complex interrelationships among genes, bacteria, and epithelial and immune responsesfocusing on cellular pathways and critical cell types that may lead to new "therapeutic targets." Determining the optimal treatment approaches and strategies through comparative effectiveness studies. The workgroup reports also identify the resources needed to carry out this ambitious research agenda, including a "centralized and distributable infrastructure" for integrated studies of IBD in humans and long-term follow-up studies of children and adults with IBD. "Through development of the ambitious research goals outlined in this document, the Crohn's & Colitis Foundation of America has again led the effort to further the understanding of IBD," said Dr. Lee Denson of Cincinnati Childrens Hospital Medical Center. "CCFA is keen to advance this research agenda in 2013 and beyond." Building on Recent Scientific and Clinical Advances The CCFA research agenda builds on recent advances in scientific and clinical research. They include major strides in IBD geneticsmore than 160 genes affecting susceptibility to Crohn's disease and ulcerative colitis have now been identified. Using sophisticated techniques, researchers have gained new insights into the complex interactions between intestinal bacteria and immune responses, including the role of specific types of immune cells. Clinical studies have improved the ability to predict the response to IBD treatment in children and to track the short- and long-term adverse effects of IBD treatments. Progress has also been made in understanding the risks and benefits of medical and surgical treatments for key patient subgroups, including pregnant women and newborns. These studies point the way toward future efforts to optimize treatment for individual patients with IBD. discover here http://www.newswise.com/articles/advances-in-inflammatory-bowel-disease-what-s-new-what-s-next
Alert the Media: Yes, Autistic kids have a Novel Bowel Disease
the children with autism, chronic gastrointestinal symptoms, who underwent clinically indicated illeo-colonoscopy were foundby the pathologist to have non-specific inflammatory prescence in their illeum or colon. We compared this group to non-autistic children who underwentcolonoscopy and ultimately were not found tohave any diagnosis. The second control group was non-autistic who had Crohn's disease confirmed on their biopsy.The third control group was non-autistic children who were found to have ulcerative colitis. DR W: So, in other words, is there an inflammatory bowel disease in these children? Number one. And, number two .. is it different from the signatures in known inflammatory bowel disease, such as,Crohn's and colitis? Is that fair? DR W: What did you find? DR K:Using microarray technology .. what we found was .. the molecularproducts of the inflammatory cells in the autistic kids was not normal. The normal patients .. when you took those bowel biopsies and you took a look at the variety of different molecules that were produced by those cells on the biopsies, they cluster in one area. When you took the biopsies of autistic children with G.I. symptoms and inflammation on biopsies .. they clustered in a second area .. and .. when you took the bowel biopsies of non-autistic crohn's and colitis patients .. they tended to cluster in a third area .. over-lapping each other. What was very interesting was that .. although the autistic children biopsies clustered in their own region, there was significant overlap with the crohn's and ulcerative colitis. But, virtually no overlap at all with the normal non-inflamed, non autistic children. DR W: Now tell me, did you look at different areas of the bowel or were you looking at just one area? source news http://www.ageofautism.com/2013/03/alert-the-media-yes-autistic-kids-have-a-novel-bowel-disease.html
Alert the Media: Yes, Autistic kids have a Novel Bowel Disease
the children with autism, chronic gastrointestinal symptoms, who underwent clinically indicated illeo-colonoscopy were foundby the pathologist to have non-specific inflammatory prescence in their illeum or colon. We compared this group to non-autistic children who underwentcolonoscopy and ultimately were not found tohave any diagnosis. The second control group was non-autistic who had Crohn's disease confirmed on their biopsy.The third control group was non-autistic children who were found to have ulcerative colitis. DR W: So, in other words, is there an inflammatory bowel disease in these children? Number one. And, number two .. is it different from the signatures in known inflammatory bowel disease, such as,Crohn's and colitis? Is that fair? DR W: What did you find? DR K:Using microarray technology .. what we found was .. the molecularproducts of the inflammatory cells in the autistic kids was not normal. The normal patients .. when you took those bowel biopsies and you took a look at the variety of different molecules that were produced by those cells on the biopsies, they cluster in one area. When you took the biopsies of autistic children with G.I. symptoms and inflammation on biopsies .. they clustered in a second area .. and .. when you took the bowel biopsies of non-autistic crohn's and colitis patients .. they tended to cluster in a third area .. over-lapping each other. What was very interesting was that .. although the autistic children biopsies clustered in their own region, there was significant overlap with the crohn's and ulcerative colitis. But, virtually no overlap at all with the normal non-inflamed, non autistic children. DR W: Now tell me, did you look at different areas of the bowel or were you looking at just one area? source news http://www.ageofautism.com/2013/03/alert-the-media-yes-autistic-kids-have-a-novel-bowel-disease.html
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