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0002). Subgroup analysis of patients with good adherence (��80%) also indicated that significant BTM response at week 22 was associated with lower nonvertebral fracture rates (uNTX: 1.3% versus 2.9%, respectively, p?=?.020, and sCTX: 1.3% versus 4.2%, p?=?.001; Table 2). Among patients with good adherence, the incidence of all fractures (nonvertebral and vertebral) also was higher in lesser responders for http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html sCTX at week 22 compared with greater responders (7.5% versus 2.3%, p?=?.0004). At 52 weeks, percentage change in spine BMD was associated with nonvertebral fracture rate; in the group of patients achieving a more than 3% LSC in spine BMD, nonvertebral fracture incidence was lower than in the group with BMD changes http://www.selleck.cn/products/BKM-120.html of 3% or less (1.4% versus 3.1%, respectively, p?=?.010; Fig. 2). However, no association was found between percentage change in hip BMD from baseline and nonvertebral fracture incidence (Table 2). Similarly, the incidence of all fractures (vertebral and nonvertebral) was positively associated with spine BMD change, but it was not associated with hip BMD change. At week 52, the incidence of all fractures was lower in the group of patients with a more than 3% LSC in spine BMD from baseline compared with those in whom BMD change was 3% or less (2.5% versus 5.1%, respectively, p?=?.015). Subgroup analysis of patients with good adherence revealed no association between spine or hip BMD change at 52 weeks and nonvertebral fracture incidence, although the incidence of all fractures was lower among those with a more than 3% LSC in spine BMD (2.6% versus 5.0%, p?=?.038). Adherence was positively associated with BTM change. At week 22 of risedronate treatment, the proportion of patients achieving a significant reduction (��30%) in uNTX or sCTX levels from baseline http://www.selleckchem.com/products/Y-27632.html was positively related with the number of doses of risedronate taken over that period (p?