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Adequate microsphere mixing was verified for each injection by the demonstration of a http://www.selleck.cn/products/lee011.html injection and expressed as VC (ml min?1 (100 g)?1 mmHg?1). All data are presented as mean �� SEM. MAP, HR and ACh responses were compared using ANOVAs with Student�CNewman�CKeuls post hoc tests where appropriate. Blood flow, VC and blood sample variables were compared with paired Student's t tests. z tests were used to determine when reductions in blood flow and VC were different from zero. Significance was accepted at P 0.05), W�� (hyperbolic: 162 �� 67, linear: 139 �� 66 J, P > 0.05) and estimated critical speed (hyperbolic: 44.0 �� 1.8, linear 1/time: 45.6 �� 1.2 m min?1, P > 0.05) were not different between models. The average running speed at which blood flow measurements were performed was 52.5 �� 1.3 m min?1 (15% above critical speed from the 1/time model). Effects of SMTC on MAP, HR and blood sample variables At rest, SMTC increased MAP and reduced HR compared to control. During exercise, http://www.selleckchem.com/products/i-bet-762.html SMTC increased MAP whereas HR was not different between conditions (Table 1). Exercising arterial blood pH (control: 7.39 �� 0.02, SMTC: 7.40 �� 0.02), (control: 85.2 �� 2.1, SMTC: 88.3 �� 3.3 mmHg), and [lactate] (control: 6.1 �� 0.4, SMTC: 6.7 �� 0.8 mmol l?1) were not different (P > 0.05 for all) http://www.selleckchem.com/products/epacadostat-incb024360.html between conditions. SMTC significantly reduced (control: 21.7 �� 0.8, SMTC: 19.8 �� 0.8 mmHg, P