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Systemic reactions are urticaria, pruritus, anxiety and nausea. More severe allergy can lead to dyspnea, asthma, angioedema, dizziness, numbness and syncope. Local reactions comprised of local swelling at injection site. Unusual reactions reported are serum sickness and generalized vasculitis.15 Side effects can be minimized by administering histamine. H. Khurrum1, K. Alghamdi1 1Dermatology, King Saud University, Riyadh, Saudi Arabia Vitiligo is a common, often distressing condition. There are many clinical coincidences between vitiligo and open http://www.selleck.cn/products/Cisplatin.html angle glaucoma (OAG). One of the basic coincidences is that both diseases are chronic, progressive and irreversible. Vitiligo is an acquired idiopathic disease, and so is POAG. To investigate and estimate the prevalence of glaucoma in vitiligo patients, as compared to healthy population. And to determine whether there is an association between periorbital topical corticosteroid use and the incidence of OAG. A prospective, cross-sectional study, ninety vitiligo patients were recruited from the dermatologic outpatient clinic. All vitiligo patients were checked for visual field, visual acuity, intraocular pressure assessment and fundoscopy by using specified ophthalmological tools. This group was compared with ninety age and gender matched healthy control group. Patients with any medical illness, including allergies, systemic corticosteroid use, diabetes mellitus, and asthma were excluded. 18�C55?yrs old patients were also excluded. Detailed eye history, including cataracts, glaucoma, other eye diseases and infections, eye trauma, and corrective lenses was also http://www.selleckchem.com/products/3-methyladenine.html taken. Detailed history about vitiligo disease including location of vitiligo, body surface area of vitiligo, duration of vitiligo, age of onset, leucotrichia, Koebner's phenomenon was noted. Family history of glaucoma, use of toxic drugs or systemic steroids, autoimmune/vascular disease or use of topical steroids around eye were noted. Descriptive analysis was used to summarize patients�� characteristics in spss, version 16.0 Statistical comparison was done by use of ��2-test and Mann-Whitney test. P? http://www.selleckchem.com/products/PD-0325901.html Only two of our vitiligo patients. Because age is a recognized independent risk factor for cataract development, the relationship between vitiligo and cataract was re-examined by restricting the comparison to patients less than 50?yrs of age. We did not find significant relationship for cataracts with vitiligo. Similarly, there was no significant relationship between cataracts of any type and topical steroid use. 19.3% use topical steroids around eye but did not develop glaucoma. 2 glaucoma patients used steroids around eyes.