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(1996) reported that with an attached macula, 63% of eyes achieved ��6/12 compared with 21% of eyes when the macula was detached. The duration of macular detachment has an effect and, in a prospective study of 283 eyes treated with PPV, 65% of eyes with the macula detached for http://www.selleckchem.com/products/Rapamycin.html significance was only observed after 14?days of detachment. It is thought that photoreceptor damage increases as the period of macular detachment increases (Isernhagen & Wilkinson 1988; Campo et?al. 1999; Speicher et?al. 2000). After PCT, a variety of mechanisms can affect vision, such as cystoid http://www.selleckchem.com/products/MG132.html macular oedema (CME), posterior capsular opacity and intraocular lens decentration, persistent corneal oedema or uveitis (Jaffe et?al. 1982; Nishi 1987; Balent et?al. 1988; Spigelman et?al. 1989; Osher & Cionni 1990; Frost et?al. 1995; Thomas et?al. 1997; Ah-Fat et?al. 1998; Ionides et?al. 2001; Blomquist & Rugwani 2002; Tan & Karwatowski 2002; Onal et?al. 2004; Ang & Whyte 2006; Johansson et?al. 2009). CME is the commonest visually significant complication, recorded in up to 21% of eyes following vitreous loss (Balent et?al. 1988; Spigelman et?al. 1989; Frost et?al. 1995; Blomquist & Rugwani 2002). The Swedish Capsule Rupture Study Group also identified persistent corneal oedema in 6.4% of eyes after a PCT compared with 1% of eyes with uncomplicated surgery (Johansson et?al. 2009). We confirmed an association between greater age and a reduced visual outcome following PRD, even after adjustment for pre-existing maculopathy, diabetes, uveitis and glaucoma. The importance of age in determining visual outcome after uneventful cataract surgery has shown previously, with patients aged more than 90?years having four times greater risk of a final acuity of http://www.selleck.cn/products/Bleomycin-sulfate.html be determined from the records beyond a description of pigmentation or scar at the macula. There are some limitations to the design of this study, namely the potential bias from the differences in follow-up time between cases and controls, and a possible loss to follow-up of cases who were transferred to other hospitals (Tuft et?al. 2006). Differences in follow-up between cases and controls could have produced spuriously high odds ratios because the cases were at risk of visual deterioration for longer after their cataract surgery than the controls.