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Height and weight were used to estimate the BMI in kg/m2. Ethnicity was defined as white (European ancestry), black (African), East Asian (China, Japan, Korea, Thailand, Vietnam, Philippines), and South Asian (Indian subcontinent, including India, Pakistan, Bangladesh, Nepal, and Sri Lanka). The a priori analyses performed included comparisons between predonation values and subsequent 12-month postdonation values for all parameters separately for donors classified as either dippers or nondippers based on their predonation 24-h ABP profile. The required sample size was estimated at a total of 48 patients in order to provide a power of 80% and alpha 0.05 at detecting a systolic BP change of 5?mmHg with an underlying normotensive population assumption for an SD of 12?mmHg. Pre to postdonation comparisons within and between the predonation dippers and nondipper groups were made by a paired or unpaired Student t-test, Wilcoxon rank sum test http://www.selleckchem.com/products/ly2157299.html or chi-square analysis as appropriate. Bivariate comparisons were made using Pearson��s correlation coefficient. A two-tailed P-value http://www.selleckchem.com/products/z-vad-fmk.html renal transplants performed from live donors (70 from biologically http://www.selleck.cn/products/s-gsk1349572.html related, 56 from emotionally related, two from paired exchange, and one from an anonymous nondirected donor). These donors constituted the eligible pool for the study. Sixty-nine (54%) patients provided initial consent for the study. Reasons for non provision of consent included unwillingness to travel to the transplant centre or provide other follow-up testing (n?=?31) foreign residence (n?=?9), or competing protocols (n?=?9). Eleven donors did not provide any specific reason for not consenting. Fifty-one (74%) consented donors completed their testing at 12?months postdonation. Their demographic characteristics are provided in Table?1. There were no significant differences noted in any predonation clinical parameters among those who completed the study and those who did not return for follow-up testing. All those who did not return reported themselves as healthy and in no need for medical follow-up. All organs were laparoscopically retrieved with no unusual vascular anatomy or subsequent surgical complications noted. Of the 51 donors, 35 were dippers and 16 were nondippers prior to donation. Changes in ABP, renal function, urine protein excretion, BMI, glucose levels, and lipid levels in both dippers and nondippers, from predonation to 12?months postdonation are summarized in Table?2.