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A logistic regression model was used to test the association between the lung donor score and donor discard primary due to donor-related medical reasons. The 1-year post-transplant outcome of patients transplanted in 2006 was studied using Kaplan�CMeier estimates and a Cox�� proportional hazards (PH) model (N?=?442). The association between the lung donor score and survival was assessed in the context of the following confounding factors: recipient age, underlying lung disease, urgency status at time of transplantation, http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html type of lung transplant (bilateral versus single), first versus retransplant, and duration of cold ischemia. All data were analyzed using the SAS software package (v6.12 SAS; Cary, NC). A total of 6080 lung donors were reported from Eurotransplant countries to the registry during the study http://www.selleckchem.com/products/Y-27632.html period (January 1, 1999 to December 31, 2007). For 3380 (55.6%) donors, at least one lung was used for transplantation. Of the donors not utilized, 72.7% (N?=?1962) were discarded for donor-related medical reasons; recipient-related medical reasons constituted the largest group (314, 42.5%) of nonutilization for other reasons (Fig.?1). Donor discard rate primarily due to donor-related medical reasons for this 9-year cohort was 36.7% (Table?1). Discard rates for the different donor characteristics in this validation set are depicted in Table?1. Table?2 shows that all the six donor factors were significantly associated with donor discard (all P-values? http://www.selleck.cn/products/pexidartinib-plx3397.html class. For example, the odds of donor discard for a donor aged 60+?years were 2.68 times greater than that of a donor under the age of 45?years, yielding 3 points. For every donor, points were summarized to yield a total score. Patients were then grouped according to their score. Figure?2 shows the number of reported donors and the discard rate stratified by value of the lung donor score. There was a direct relationship between the value of the score and the likelihood that a reported lung donor was discarded for donor-related medical reasons (P?