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[10] PSM, defined as cancer cells reaching the inked surface of the specimen, were categorized into four groups according to the following locations: apex, base, posterolateral and multifocal. https://en.wikipedia.org/wiki/Crotamiton The prostate volume was measured by preoperative transrectal ultrasonography according to the prolate ellipsoid formula (��/6?��?D3). The patients were divided into four equal quadrants depending on their prostate volume: http://www.selleckchem.com/products/CP-673451.html intraperitoneal approach described previously as the Montsouris technique.[11] The choice http://www.selleckchem.com/products/rxdx-106-cep-40783.html of surgical modality accorded with each patient's preference after discussion of the risks, benefits and alternatives with the attending surgeon. Comparisons between participant groups were carried out using the Student's t-test or Pearson's ��2-test. Preoperative variables were established by univariate analysis, and those determined to be significant were subjected to a multivariate analysis incorporating a logistic regression model. The numbers of LRP cases at each positive location were too small, so it is not possible to carry out the statistical analysis. In the analysis of predictive factors for PSM locations, we only carried out regression analysis with ORP and RALP cases. A two-sided P-value less than 0.05 was considered significant; all P-values were two-sided. All of the tests were carried out with the spss software package (version 14.0; SPSS, Chicago, IL, USA). The patient demographics along with the perioperative clinicopathological characteristics are listed in Table?1. A statistically significant larger prostate volume was present in patients treated by ORP compared with those treated by RALP and LRP. Based on the risk stratification, 1141 (35.4%), 1115 (34.6%) and 971 (30.1%) patients were classified as having low-, intermediate- and high-risk disease, respectively. ORP patients had higher-risk diseases compared with those of RALP and LRP.