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?2, indicating that the LDF parameters were not depending upon the DC value. In Fig.?3, ChBF values are plotted as a function of the corresponding values of ChBVel in patients with EMG. The two Doppler flowmetry parameters were significantly correlated (p http://www.selleck.cn/products/Bleomycin-sulfate.html as box plots for control subjects and patients with EMG. Mean PERG amplitude was significantly reduced by 46% (p? http://www.selleckchem.com/products/Rapamycin.html with EMG and in control subjects. This study was designed to http://www.selleckchem.com/products/MG132.html evaluate whether subfoveal choroid blood flow is altered in patients with EMG and whether this alteration is associated with central retinal dysfunction as detected by PERG. Our results indicate that ChBF was significantly reduced in patients with EMG, primarily because of a decrease in ChBVel, whereas ChBVol did not appear to be affected. The DC values in patients with EMG were significantly increased on average when compared to control values. This could be due to early micro-anatomic changes involving the choriocapillaris layer of glaucomatous eyes, resulting in a general increase in the reflectance backscatter of the subfoveal tissue. DC changes likely did not affect the results of ChBF, because no correlations between DC values and each LDF parameter were found in both control subjects and patients. Even if an impaired vascular auto-regulation is generally accepted as the main cause of ocular blood flow reduction in glaucomatous eyes (Flammer et?al.1999; Grieshaber et?al. 2007; Moore et?al. 2008; Mozaffarieh et?al. 2008), alterations in the choriocapillaris micro-vascular architecture could play an additional role in increasing the resistance and, consequently, reducing velocity and flow of the subfoveolar choriocapillaris blood stream. In his study, Spraul et?al.