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04), in particular for lesions also detected with ceT1W images (53 versus 40; P?=.01). There was no significant difference between the number of lesions detected with combined nFLAIR and ceT1W sequences compared to those detected with ceFLAIR (82 versus 76; P?=.25). Use of ceFLAIR as a complementary sequence to nFLAIR and ceT1W sequences did not improve the detection of brain lesions and cannot be recommended as part of a routine brain MRI protocol in dogs and cats with suspected brain lesions. ""Cavalier King Charles Spaniels (CKCS) have a high prevalence of Chiari-like malformation (CM). Herniation of the cerebellum into the foramen magnum is a key diagnostic feature for CM. Midsagittal MR images are the preferred technique for visualizing cerebellar http://www.selleckchem.com/products/Adriamycin.html herniation (CH). To investigate whether CT can be used to diagnose CH. Fifteen client-owned CKCS dogs referred for investigation of the brain and cranial cervical spine on MRI and CT. Two reviewers retrospectively analyzed midsagittal T1WSE and T2WSE MR images http://www.selleck.cn/products/dabrafenib-gsk2118436.html and midsagittal pre- and postcontrast 2D multiplanar reformatted CT images from each dog for the presence of CH. And, if present, the length (mm, CHL) of the herniation was measured. The results were analyzed statistically. There was no significant difference between the different observers and techniques for the detection of CH and measurement of CHL. Overall, the CHL was longer on the CT images. Both techniques are useful for detecting CH and measuring CHL. Because CHL does not have a known direct impact on the clinical presentation of CM, CT can be used as a diagnostic tool in a routine clinical practice for CM in CKCS when MRI is not available. We emphasize that MRI is the standard screening technique in CKCS for breeding purposes to detect the presence of CM and SM and, at the current time, CT cannot replace MRI. ""Trilostane is commonly used to treat pituitary-dependent hyperadrenocorticism (PDH) in dogs. There are differing opinions regarding the dose and frequency of trilostane administration in dogs with PDH. To compare the efficacy of 2 trilostane protocols in the treatment of dogs with PDH. Sixteen client-owned http://www.selleckchem.com/products/DAPT-GSI-IX.html dogs with PDH and a body weight