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The decision to perform AVR in octogenarians remains a challenge, mainly due to increased operative morbidity and mortality. Most patients aged ��80?years with severe AS either refuse or are not proposed for AVR [9-12], despite evidence that AVR can be performed in selected octogenarians with relatively low mortality [4, 13-21]. Transcatheter aortic-valve implantation (TAVI) has emerged as an alternative to AVR for patients considered high operative risk and to medical management in patients who cannot undergo surgery [22-24]. We aimed to describe the baseline characteristics of octogenarians with symptomatic severe AS, to analyse the http://www.selleck.cn/products/AZD6244.html factors that determine the choice of treatment and to evaluate the variables that affect long-term clinical outcome. PEGASO was a prospective, observational, multicenter registry conducted in Spain between 1 July 2008 and 30 June 2010. Data were collected online with predefined ranges, controls to prevent repetitive inclusions and erroneous data entry alerts. The application was developed in collaboration with SATEC (Advanced Systems Technology, http://www.selleckchem.com/products/lee011.html Inc., Madrid, Spain). All fields were examined for extreme values, and investigators were asked to correct data if necessary. The inclusion criteria were as follows: (i) age ��80?years; (ii) severe AS with a mean aortic-valve gradient >40?mmHg or an aortic-valve area http://www.selleckchem.com/products/bmn-673.html participated in the registry: 17 (46%) were hospitals with a cardiac surgery department and catheterization laboratory, 7 (19%) with a catheterization laboratory only and 13 (35%) with neither. 15 (41%) were university hospitals and only 4 (11%) were private hospitals. The study complies with the Declaration of Helsinki and was approved by the Ethics Committee of Hospital General Universitario Gregorio Mara?��n of Madrid, Spain. Variables included biodemographic data, physical examination findings, cardiovascular risk factors, previous disease, blood test results, echocardiographic parameters at baseline and current drug treatment.