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Strokes were significantly more severe in centenarians (mean SSS 25.4; Fig.?1; P? http://www.selleck.cn/products/gsk-j4-hcl.html was also significantly higher in the centenarians (38.5%; Fig.?2; P? http://www.selleckchem.com/products/byl719.html the centenarians with stroke presented in the present study should be considered representative of centenarians with stroke in Danish hospitals rather than representing the centenarian stroke population. We are not aware of any other report on characterization of strokes among centenarians. Because numbers were small, data on the centenarians in comparison with other age groups are not suitable for statistical processing, and they should be interpreted with caution. The traditional risk factors for stroke are all associated with excess mortality.[13] Therefore, mortality displacement (i.e. decrease in prevalence of the risk factor in the population due to excess mortality of individuals having the risk factor)[14] is the http://www.selleckchem.com/products/BEZ235.html most likely explanation of the relatively low prevalence of stroke risk factors in centenarians than in the other age groups with stroke. This phenomenon finds expression as early as in the 70s, where the prevalence of most cardiovascular risk factors in stroke patients begins to decline.[15] Thus, a better risk factor profile appears to be involved in delaying the occurrence of stroke to a very old age. The relatively lower prevalence of traditional risk factors for stroke in centenarians (and in the oldest old as a whole) in the present study supports findings in the Leiden 85�� study[16] that the relationship between traditional cardiovascular risk factors and cardiovascular events weakens in the oldest old, with other factors being important. Stroke severity increases with age,[17] and strokes were also markedly more severe among centenarians in the NIP stroke cohort. Stroke severity and age are the two most important predictors of short-term, as well as long-term, survival in stroke.[18] Accordingly, mortality was also greatest in the centenarians in our cohort. In Scandinavia, the stroke hospitalization rate is high �C 90% or more.[2, 19] The rate of non-hospitalized stroke patients increases with increasing age.