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""Martinez-Mier G, Avila-Pardo SF, Mendez-Lopez MT, Budar-Fernandez LF. Long-term results after conversion from calcineurin inhibitors to sirolimus in renal transplant patients. http://www.selleckchem.com/products/MDV3100.html Clin Transplant 2010: 24: 467�C473. ? 2009 John Wiley & Sons A/S. Abstract:?Background:? Calcineurin inhibitors (CNI) toxicity is one of the contributing factors for the development and progression of chronic allograft dysfunction (CAD). Conversion to sirolimus (SRL) from CNI improves renal function kidney in transplant recipients. Methods:? A retrospective review from patients abruptly converted from CNI to SRL over a three yr period is reported. Results:? Thirty-nine patients were converted 55.2?��?58?months after renal transplantation. 24?month patient and graft survival was 100% and 92%. Acute rejection incidence was 7.6%. Overall, serum creatinine (SCr) and Cockcroft�CGault creatinine clearance (CGCrCl) improved. In responders, SCr improved from 2.48?��?0.8 to 1.94?��?0.8?mg/dL (p? 25: E579�CE583. ? 2011 John Wiley & Sons A/S. Abstract:? Renal function is thoroughly evaluated before live kidney donation. However, some donors experience impaired recovery of renal function after donation. Our aim was to assess estimated glomerular filtration rate (eGFR) and mean relative (%) increase in creatinine one yr after donor nephrectomy. The study was based on retrospective data from kidney donors during the period 1997�C2009. Pre-operative and one-yr follow-up data were available for 721 of 1067 donors. Mean relative increase in creatinine and eGFR were stratified by gender, body mass index (BMI), and age at donation. At one yr post-donation, overweight (BMI?>?25?kg/m2) women 50?yr or older experienced the lowest eGFR of 49.6?��?8.8?mL/min/1.73?m2. Men younger than 50?yr with normal weight (BMI?