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We also came across a case study describing a 17-year-old virginal adolescent with exceptionally persistent BV, which was completely cured by a multisession H2O2-douching regimen. The patient was seeking medical help because of ��extraordinarily malodourous�� vaginal discharge; however, her symptoms were unresponsive to conventional antibiotic treatments during the 6?months preceding the experimental trial. Further examination by Papanikolaou et?al. (2002) revealed G.?vaginalis and other anaerobes in the girl��s vaginal secretions. The secretions were also positive for clue cells, an elevated pH?>?4��5 and the amine ��whiff�� test. Following yet another unsuccessful metronidazole regimen, the patient was given a douche containing a 3% H2O2/15% NaCl/10% povidone iodine solution which was administered daily http://www.selleckchem.com/products/bmn-673.html for ten consecutive days. Additionally, the girl��s vaginal walls were cleansed during each session using small gauze, which http://www.selleckchem.com/products/pexidartinib-plx3397.html probably assisted in removal of pathogenic biofilms. Remission of all the symptoms was documented a month after the treatment, and the patient remained symptom-free during the year that followed. Repeated vaginal washouts with H2O2 accompanied by a mechanical removal of biofilms may potentially be an effective treatment for BV, which is worth investigating in a well-controlled clinical trial. In a cohort study conducted by Cardone et?al. http://www.selleck.cn/products/nlg919.html (2003), 3% hydrogen peroxide was vaginally administered to 58 nonpregnant women with recurrent BV on a daily basis for the duration of 1?week. Three months after the treatment, a great majority of the participants was no longer affected by the clinical symptoms of BV: 98% had a vaginal pH?