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These preliminary incidence estimates suggest that atypical femur fractures are rare in the general population, but may be more common among patients with longer-term http://www.selleck.cn/products/LY294002.html oral bisphosphonate use. Disclosures: Susan Ott, None. 1202 Long-term Mortality after Low-energy Fractures at Middle-age - a Study of 22 000 Men and 11 000 Women.Anna H Holmberg*1, Jan-?ke Nilsson1, Peter M Nilsson2, Kristina ?kesson3. 1Dpt of Orthopedics, Sk?ne University Hospital, Malm?, Sweden, 2Dpt of Internal Medicine, Sk?ne University Hospital, Malm?, Sweden, 3Dpt of Clinical Sciences, Malm?, Clinical & Molecular Osteoporosis Research Unit, dpt of orthopedics, Skane University Hospital, Malm?, Sweden The aim of this study was to examine long-term effects http://www.selleckchem.com/products/obeticholic-acid.html of a low-energy fracture on mortality rates in an urban middle-aged population. How long does the increased mortality risk persist? What types of fractures influence mortality risk? Are there any sex differences in mortality rates? Methods: The Malm? Preventive Project consists of 10902 women and 22444 men, mean age at inclusion 50 and 44 years respectively. The subjects were followed prospectively regarding fractures and mortality up to 32 years. The subjects were subdivided according to sex and age at first fracture; http://www.selleckchem.com/products/Adriamycin.html Standardised mortality rates (SMR), adjusted for age, sex and calendar year, were calculated per 100 person-years (p-yrs) with data from Statistics, Sweden, using the southern region (approx. 1 000 000 inhab) as background population. Dates of death was obtained from the National Board of Health and Welfare, Sweden. Results: 2069 women and 1800 men sustained fractures and of these 332(16%) women and 648(36%) men died. In women, sustaining any type of fracture increased the 25-yr mortality risk in all ��50 yrs (SMR 126-237/100 p-yrs, CI 95% 102-295). A hip fracture at age 60 or more increased the 25-yr mortality risk up to 6 times (SMR 293-601/100 p-yrs, CI 95% 184-852). Vertebral fractures increased the 25-yr mortality risk in women 60-69 yrs (SMR 233/100 p-yrs, CI 95% 101-364). In men, sustaining any type of fracture increased the mortality risk in all age groups up to 25 yrs (202-284/100 p-yrs, CI 95% 174-329). A hip fracture at age 50 or more increased the 25-yr mortality risk up to 4 times (391-463/100 p-yrs, CI 95% 249-598). Vertebral fractures increased the mortality risk up to 25 yrs post-fracture in all age-groups (SMR 260-375/100 P-yrs, CI 95% 133-607).