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""Hiroshi Kanamaru et?al. carried out preoperative renal scintigraphy in patients who underwent unilateral nephrectomy and investigated whether it is valuable for predicting the long-term renal function.1 They concluded that renal scintigraphy had less value than estimated glomerular filtration rate (eGFR). As the authors mentioned, the reason why preoperative eGFR predicted postoperative eGFR more effectively than contralateral effective renal plasma flow (cERPF) was simply because the renal function goal they used was not ERPF, but eGFR. The renal function on the resected side influences postoperative value.2 Meanwhile, compensatory hyperfunction occurs in the normal side before surgery, when the renal function on the resected side is disturbed by large tumors, therefore, it stands to reason that preoperative total eGFR has a correlation with postoperative eGFR. Still, if they investigate the relationship between preoperative eGFR?��?cERPF/total ERPF (tERPF) and http://www.selleckchem.com/products/rxdx-106-cep-40783.html postoperative eGFR, https://en.wikipedia.org/wiki/Crotamiton it would be more predictable. From the results of this study (fig.?1f) and some previous studies,2�C4 postoperative renal function after nephrectomy is approximately 60�C80% of preoperative value. The merit in omitting scintigraphic evaluation is that it saves on costs and time, meanwhile, the differential renal function should be assessed accurately before nephrectomy, especially in patients who have low renal function, are scheduled for adjuvant chemotherapy/molecular targets and so on. Such patients are candidates for renal scintigraphy, or at least should be assessed using the recently reported formula for predicting postoperative renal function from preoperative computed tomography scan images.3 ""To investigate the efficacy of urine alkalization therapy using citrates in patients with hypersensitive bladder syndrome. A total of 76 patients with urinary frequency were assessed for their symptoms using a 2-day voiding diary as well as the urine pH at each voiding during the screening period. Their symptoms were also assessed by pain score, King's health questionnaire, and O'Leary�CSant symptom and problem index scores. Finally, 50 patients were evaluated for changes in symptoms after oral treatment with citrates for 2�C4?weeks after the screening period. After the treatment, significant increases in the urine pH (from 5.8?��?0.4 to 6.3?��?0.4; increment of 0.5?��?0.4; P? http://www.selleckchem.com/products/CP-673451.html micturitions per day (from 14.5?��?6.5 to 13.5?��?5.9; P?=?0.02) and the number of episodes of pain/discomfort per day (from 7.8?��?6.8 to 6.1?��?7.1; P?=?0.02) were observed. In the King's health questionnaire, the sleep/energy domain score was significantly improved (from 60.0?��?25.0 to 50.3?��?29.6; P?