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The Spearman correlation test was used to test the correlation between cancer stage and the interval between endoscopies (months) http://www.selleck.cn/products/gsk126.html in patients with a previous history of endoscopy. To analyze the relationships between the 7 endoscopy interval groups and the stages of gastric cancer, ordinal logistic regression was used, and odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined. The endoscopy interval was the independent variable and was adjusted for age and sex. We also estimated the OR for each endoscopy interval group compared to the never-screened group by logistic regression after adjusting for age and sex. Logistic regression and P for trend were used to estimate the ORs for AGC and EGC compared to the 1-year interval group. Logistic regression analysis was performed without the use of an elimination method. We stratified analyses by age, sex, family history of gastric cancer (defined as cancer in first- or second-degree relatives), tumor location, histological tumor differentiation, and Lauren's classification15 to investigate which groups would benefit from frequent endoscopy. In the subgroup analysis, ordinal logistic regression was used to analyze the relationships between the 7 endoscopy interval groups and gastric cancer stages. All P values are 2-sided, and significance is indicated by P http://www.selleckchem.com/products/BI-2536.html adenocarcinoma http://www.selleckchem.com/products/Cyclopamine.html (n = 6) or gastric adenoma (n = 19); a previous history of gastric resection (n = 7); an endoscopy was performed on the patient within 6 months of diagnosis (n = 6); the lack of pathological confirmation of gastric adenocarcinoma (n = 13); or the presence of multiple gastric cancers (n = 132). The baseline demographics and tumor characteristics of the 2485 enrolled patients are shown in Table 1. The mean age was lower in patients with stage IV cancer (55.4 �� 12.1 years) than in those with either stage I (58.0 �� 11.5 years; P