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In these models, all 471 patients were incorporated, including those who died during the first 100?d post-transplantation. Collinearity was checked by calculating Variance inflation factors (VIF) for each variable included in a multivariate Cox model. Since VIF http://www.selleckchem.com/products/jq1.html was of death-censored graft loss, competing risks from death were also assessed by the method described by Fine and Gray [9]. All statistical tests of significance were two-tailed, and p? accidents without aneurysms n?=?16 and ruptured aneurysms n?=?4. Median time from transplantation to cardiovascular death was 6.8 (IQR 3.4�C9.7)?yr. One patient died abroad without information whether with or without graft function. The causes of graft loss were considered as chronic allograft nephropathy in 102 patients, recurrence of disease in nine patients and urologic complication in one patient. In three patients, the graft was never functioning and in another three patients the cause remained unknown. Eighteen patients lost the graft function during the first 100?d. The total number of uncensored graft losses was 283 (60.1%) and of death-censored graft losses 118 (25.1%). In preliminary analyses, asymptomatic CMV infection and CMV disease were tested as a categorical risk factor for overall mortality. In a multivariate Cox proportional hazard model adjusting for asymptomatic CMV infection and CMV disease as a categorical covariate, patient age, preemptive transplantation, HLA-DR one and two vs. zero mismatches, HLA-AB one to four vs. zero mismatches, living donor, acute rejection during the first 100?d and diabetic nephropathy; only asymptomatic CMV infection but not CMV disease was significantly associated with overall mortality, hazard ratio (HR)?=?1.507, 95% CI 1.086�C2.090, p?=?0.014 and HR?=?1.249, 95% CI 0.834�C1.871, p?=?0.28, respectively. Furthermore, virus load expressed as area under the curve (AUC) for CMV pp65 was evaluated as risk factor for mortality [6]. Patients were divided into two groups with high (AUC?��?707) and low (AUC?